Mutagenic properties of dimethylaniline isomers in mice as evaluated by comet, micronucleus and transgenic mutation assays
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منابع مشابه
Assessment of the in vivo genotoxicity of isomers of dinitrotoluene using the alkaline Comet and peripheral blood micronucleus assays.
Dinitrotoluene (DNT) is a nitroaromatic explosive that exists as six isomers; two major isomers (2,4- and 2,6-DNT) and four minor isomers (2,3-, 2,5-, 3,4-, and 3,5-DNT). DNT has been found in soil, surface water, and groundwater near ammunition production plants. The major isomers of DNT are classified as "likely to cause cancer in humans."In vitro studies have provided conflicting data regard...
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Mercury is a toxic element which is easily absorbed after ingestion or inhalation and deposited mainly in the kidney. The aim of this study was to evaluate the effects of mercury chloride in rats. Female rats, aged 14 weeks, were receiving mercury chloride in oral doses of 0.068, 0.136, and 0.272 mg kg(-1) body weight (b.wt.) for five consecutive days. Three days after the last dose, the animal...
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Orthodontic appliances are usually made of stainless steel, which contains metals such as nickel, chromium and iron that have been associated with DNA damage. The aim of the present study was to determine the genetic toxicity associated with orthodontic fixed appliances in twenty healthy patients (16 +/- 2.5 years) undergoing orthodontic treatment (fixed appliances - basic composition: stainles...
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Genotoxicity studies on toxic metals and their organic compounds are very important, especially so in the investigation of the effects of these compounds on the aquatic environments where they tend to accumulate. The use of endemic aquatic organisms as biological sentinels has proved useful to environmental monitoring. We assessed the mutagenic potential of tributyltin (TBT) and inorganic lead ...
متن کاملMutagenic carcinogens and noncarcinogens in transgenic mice.
Multi-antibiotic resistant Gram-positive cocci, which include Staphylococcus aureus, the coagulase-negative staphylococcal group, Enterococcus faecalis and Enterococcus faecium, and other streptococci, represent emerging pathogens especially in the setting of the immunocompromised, hospitalized patients, in particular when surgery, invasive procedures, or prosthetic implants are of concern, pat...
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ژورنال
عنوان ژورنال: Genes and Environment
سال: 2018
ISSN: 1880-7062
DOI: 10.1186/s41021-018-0106-3